Calcium-D-Glucarate: Breast Cancer Protection and Liver Support in One  

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Blog | Jan, 07 2020

Calcium-D-Glucarate: Breast Cancer Protection and Liver Support in One  

How you “assimilate and eliminate” is just as important as what you put in your body. Making sure that detoxification is working for you means taking care of the major organs and systems that are involved in the process, especially the liver. Research is discovering a little-known substance called Calcium-D-glucarate that may provide great benefits for the liver and may even help to prevent Breast Cancer overall as well.  

What is Calcium-D-Glucarate?

All mammals naturally produce a detoxifying chemical compound called glucaric acid in small amounts. Glucaric acid is also found in some whole foods such as apples and cruciferous vegetables. Calcium-D-glucarate, or CDG, is the supplement form of glucaric acid. It is created by combining glucaric acid with calcium salt compounds. Once taken, the body then converts CDG back into a form of glucaric acid, which it can then safely absorb.

Before modern times, people and other mammals got enough glucaric acid from organic internal production as well as by eating whole foods. As the amount of toxins in our world increases, however, the amount of glucaric acid that we need increases as well.

3 Ways Calcium-D-Glucarate Can Help You

#1 Removing toxins.

Besides being packed with cancer-busting sulforaphane, cruciferous vegetables are also a good source of glucaric acid. The best way to get enough, however, is to supplement with CDG.

Glucaric acid is a “toxin scavenger.” It is specifically designed to bind to toxins in the body and usher them out through the urine. Glucaric acid is present throughout the body, but it is in the liver where CDG is most beneficial. 

According to a 2002 report for Alternative Medica Review, CDG slows down and may even prohibit the production of a substance called beta-glucuronidase. Beta-glucuronidase is an enzyme that is produced by microflora in the colon. During Phase II detoxification, it can destroy key components involved in a process called conjugation. Conjugation is one of the main ways that the body rids itself of toxins.

During conjugation, compounds called glucuronides are formed. Glucuronides are like tiny “water bubbles” which help to transport toxins out of the body. Glucuronides are self-contained and can pass safely through the liver, the bile, and the gut to eventually be expelled.

This is where Calcium-D-glucarate comes in. With the help of CDG, glucuronide “lipid bubbles” stay intact and are able to do their job of ushering toxins out the door. 

#2 Helping to digest protein.

The liver and kidneys are designed to process proteins in a timely and effective way. When these organ systems become overtaxed is when problems can arise.

CDG can be helpful as a supplement for those sticking to a ketogenic diet. It can also help anyone who consumes high amounts of protein. This is because, as CDG supports the liver and cleans up toxins, it also provides support for the assimilation and breakdown of proteins.  

#3 Balancing Estrogen Levels.

CDG has proven to be very helpful in maintaining healthy estrogen levels.

Supplementing with Calcium-D-glucarate may balance estrogen levels as well. The reason for this, again, is what CDG can do to inhibit beta-glucuronide enzymes.

Beta-glucuronides assist in maintaining estrogen homeostasis when they are present in the right numbers. But when they grow out of control, however, is when estrogen-related problems, including Breast Cancer, can occur.

According to many research studies, high levels of this particular enzyme can eventually ramp up the number of estrogen receptors in the body. More receptors for estrogen mean more places for xenoestrogens, or dangerous aggressive estrogen mimickers to land. High amounts of xenoestrogens have been linked to numerous reproductive issues, including Breast Cancer in both men and women and prostate cancer in men.

In vivo investigations dating back to the 1990s found that CDG supplementation can provide “antiproliferative effects” on mammary tissue, indicating that it may be a strong protectant against Breast Cancer.

An in-depth analysis of the benefits of CDG published by the Townsend Report cites several studies that make the link between CDG use and Breast Cancer protection.

One study sponsored by Memorial Sloan-Kettering Cancer Center and published in the 1995 edition of the Israel Journal of Medical Sciences was done on rats who had a 100% chance of developing Breast Cancer. A little over half of those treated with CDG actually developed tumors. Of those, roughly 87% fewer tumors were found.

Consuming foods high in glucaric acid or taking a CDG supplement may help prevent cancer in general as well. According to a 2003 report published in the journal Integrative Cancer Therapies, “[t]here is now growing evidence for the possible control of different stages of the cancer induction by inhibiting β-glucuronidase with d-glucaric acid derivatives, especially with its salts (d-glucarates).”

In addition to all this, research also indicates that CDG supplementation may be beneficial at balancing cholesterol levels, for rejuvenating the adrenal glands, and kidney health, and for the healthy function of metabolic and detoxification pathways overall.

The Main Take-Away Regarding Calcium-D-Glucarate

If are feeling weak, tired, lethargic, inflamed, moody, or fatigued on a regular basis, or if you are on a healing journey with Breast Cancer, there is a good chance that an overload of toxins has something to do with it. 

New research into the benefits of Calcium-D-glucarate is exciting. It shines the light on just how vitally important detoxification is for staying cancer-free and feeling great—and it lays out a clear way to help these pathways out as well! Head to the store and pick up a bottle of CDG  to help support your healthy estrogen levels. 



    • I did a bit of research and don’t find anything that is specifically related to prostate cancer. CDG is something that the body manufactures in small quantities. It helps to keep toxins “tightly packaged” in order to be excreted from the body without doing further harm. Knowing this, I would believe the answer is yes, but please check with your doctor if you will be taking a supplement rather than just getting it dietarily.